منابع مشابه
Navigating the ribosome's metastable energy landscape.
The molecular mechanisms by which tRNA molecules enter and transit the ribosome during mRNA translation remains elusive. However, recent genetic, biochemical and structural studies offer important new findings into the ordered sequence of events underpinning the translocation process that help place the molecular mechanism within reach. In particular, new structural and kinetic insights have be...
متن کاملMetastable Dynamics and Spatially Inhomogeneous Equilibria in Dumbell-shaped Domains
The motion of internal layers for three singularly perturbed reaction diiusion problems, including the Allen-Cahn equation, is studied in a two-dimensional dumbell-shaped domain. The channel region that connects the two attachments, or lobes, of the dumbell is taken to be rectangular. The motion of straight-line internal layers in the channel region is analyzed using an asymptotic projection me...
متن کاملThe multiple-specificity landscape of modular peptide recognition domains
Modular protein interaction domains form the building blocks of eukaryotic signaling pathways. Many of them, known as peptide recognition domains, mediate protein interactions by recognizing short, linear amino acid stretches on the surface of their cognate partners with high specificity. Residues in these stretches are usually assumed to contribute independently to binding, which has led to a ...
متن کاملMetastable Dynamics and Exponential Asymptotics in Multi-dimensional Domains
Certain singularly perturbed partial diierential equations exhibit a phenomenon known as dynamic metastability, whereby the solution evolves on an asymptotically exponentially long time interval as the singular perturbation parameter tends to zero. This article illustrates a technique to analyze metastable behavior for a range of problems in multi-dimensional domains. The problems considered in...
متن کاملIsotropy and Metastable States the Landscape of the Xy Hamiltonian Revisited
The number of local optima is an important characteristic of a landscape. It appears to depend on the pair-correlation of the landscape as well as on its deviations from statistical isotropy. We use Tanaka and Edward's XY Hamiltonian as an example for an investigation of the relationships between ruggedness, metastable states, and isotropy.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of High Energy Physics
سال: 2008
ISSN: 1029-8479
DOI: 10.1088/1126-6708/2008/06/014